1. Prepare griddle for medium heat. Lightly spray 1 side of each tortilla with cooking spray.
2. Place 1 tortilla on griddle sprayed side down. Spread pizza sauce evenly over tortilla. Layer half the cheese, pepperoni, and remaining cheese. Top with remaining tortilla.
3. Cook 3 to 4 minutes or until golden brown. Turn over; cook additional 3 to 4 minutes. Cut into wedges.